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镁基生物医用材料研究室简介
 
镁作为人体所必需的营养元素,具有良好生物力学性能和出色的生物相容性,特别是生物体内可降解吸收, 可以避免二次手术,其应用前景被广大医疗工作者普遍看好,近年来在国际上被誉为“革命性的金属生物材料”。本研究室基于轻合金精密成型国家工程研究中心在高性能镁合金材料领域的研究积累,专注于两类可降解医用镁合金材料的研发及其表面改性的研究:1)高强度中等塑性医用镁合金材料,目标:骨科内植物。2)中等强度高塑性医用镁合金材料,目标:心血管支架、气管、胆管等支架的临床应用。同时与企业合作进行相关可降解医疗器械的研发。
1. 研究室成员介绍:
主任:袁广银 教授
主要研究人员:章晓波 博士
博士研究生:张松、褚振华、黄华、毛琳、张健
硕士研究生:宗阳、牛佳林、童剑
已经毕业研究生:刘勇(博士,2008),尹健(博士,2009),张新平(硕士,2008),张鉴(硕士,2008),张佳(硕士,2009)
 
2. 研究室主要研究方向:
(A) 可降解医用镁合金材料(骨科内植物、心血管支架类)设计、组织控制与强韧化;
(B) 生物材料表面改性及其生物相容性研究;
(C) 大块非晶与准晶材料
 
3. 研究进展:
研发的专利生物镁合金JDBioMg(JDBM)具有良好的生物相容性

 
可降解镁合金医疗器械的研发
 
4. 研究室医学临床领域主要合作伙伴:
(A) 上海交通大学附属第六人民医院骨科
(B) 上海交通大学附属第九人民医院骨科
(C) 上海中山医院心内科
(D) 上海交通大学附属第一人民医院内科
 
5. 研究室代表性著作:
2) Chunxi Yang, Guangyin Yuan, Jia Zhang, Ze Tang, Xiaoling Zhang, Kerong Dai, Effects of magnesium alloys extracts on adult human bone marrow-derived stromal cell viability and osteogenic differentiation, Biomed. Mater.5(2010) 045005.
3) Guangyin Yuan, 大会报告“Research on Mg-Nd-Zn-Zr Alloy as a Biodegradable Stent Material”, 2nd Symposium on Degardable Metals for Biomedical Applications, Aug.31-Sep.4,2010, Maratea, Italy.
4) 张佳,宗阳,袁广银,丁文江,镁合金在生物医用材料领域的应用及发展前景,中国组织工程研究与临床康复,Vol.13(29)2009年,5747-5750
5) 张 佳,宗 阳,袁广银,丁文江等,新型医用Mg-Nd-Zn-Zr 镁合金在模拟体液中的降解行为,中国有色金属学报,2010,10.
6) Jian Yin, Guangyin Yuan, Zhenhua Chu, Jian Zhang, Wenjing Ding, Formation, microstructure and mechanical properties of in situ Mg-Ni-(Gd,Nd) bulk metallic glass composite, J.Mater.Research, 2009, 2412)3603-3610.
7) J.Yin,G.Y.Yuan, W.J.DingMg–Ni–(Gd,Nd) bulk metallic glasses with improved glass-forming ability and mechanical properties, J.Mater.Research, 2009, 24(6),2130-2140.
8) W. J. Ding , Y. J. Wu , L. M. Peng, X. Q. Zeng , G. Y. Yuan, D. L. Lin, Formation of 14H-type long period stacking ordered structure in the as-cast and solid-solution-treated Mg-Gd-Zn-Zr alloys, J.Mater.Research, 2009,24(5)1842-1851.  
9) J. Yin, G.Y. Yuan, P.F. Wang, J. Zhang, Z.H. Chu and W.J. Ding, Effects of the partial substitutional alloying elements on the crystallization behavior of Mg65Cu25Gd10 bulk metallic glasses: Ag versus Ni,  Journal of Alloys and Compounds, 4812009)407-410.
10)Wu, G., Zeng, X., Yuan, G, Growth and corrosion of aluminum PVD-coating on AZ31 magnesium alloy Materials Letters, 62(28), 2008, p 4325-4327
11)张新平,袁广银,刘勇,丁文江,合金元素对Mg-Zn-Gd合金组织和力学性能的影响,特种铸造及有色合金,2008,28(11), 882-884。
12)张鉴,张新平,袁广银,张松,丁文江,不同准晶含量的Mg-Zn-Gd-Y合金的高温热压缩变形行为,中国有色金属学报,2009,19(5)pp.793-799.
13)Liu, Y. Yuan, G., Lu.C., Ding, W, The role of nanoquasicrystals on the ductility enhancement of as-extruded Mg-Zn-Gd alloy at elevated temperature Journal of Materials Science 43 (16),2008 pp. 5527-5533
14)Guangyin Yuan, Yong Liu, Chen Lu, Wenjiang Ding, Effect of quasicrystal and Laves phases on strength and ductility of as-extruded and heat treated Mg–Zn–Gd-based alloys, Materials Science and Engineering A (2008), 472(1-2), P.75-82.
15)Guangyin Yuan, Yong Liu, Wenjiang Ding, Chen Lu, Effects of extrusion on the microstructure and mechanical properties of Mg-Zn-Gd alloy reinforced with quasicrystalline particles, Mater.Sci.& Eng.A, 2008, 474/1-2, p.348-354.
16)Yong Liu, Guangyin Yuan, Song Zhang, Xinping Zhang, Chen Lu and Wenjiang Ding , Effects of Zn/Gd ratio and content of Zn,Gd on phase constitutions of Mg alloys, Materials Transactions49(5)(2008) 941-944
17)Yong Liu, Guangyin Yuan, Jian Yin, Wenjiang Ding, et al., The effect of cooling rate on the microstructure and mechanical properties of Mg - Zn - Gd-based alloys, International Journal of Materials Research, 99 (9)2008)973-978.
18)Yong Liu, Guangyin Yuan, Wenjiang Ding and Cheng LuDeformation behavior of Mg-Zn-Gd-based alloys reinforced with Quasicrystal and Laves phases at elevated temperatures,J. Alloys and Compounds427(2007)160-165.
19)M.Zhang,W.Z.Zhang, G.Y.Yuan, Q.L.Zhao, Microstructure and precipitates in Mg-Zn-Y alloys, Materials Science Forum, 546-549(2007)203-206.
20)Yong Liu, Guangyin Yuan, Cheng Lu and Wenjiang Ding, Stable icosahedral phase in Mg-Zn-Gd alloy, Scripta Materialia, 55(2006)919-922.
21)Guangyin Yuan, Hidemi Kato, Kenji Amiya and Akihisa Inoue, Excellent creep properties of Mg-Zn-Cu-Gd-based alloy strengthened by quasicrystals and Laves phases, J.Mater.Research, (2005) 20(5), 1278-1286. times cited:18
22)Guangyin Yuan, Kenji Amiya, Hidemi Kato, Akihisa Inoue, Structure and mechanical properties of cast quasicrystal-reinforced Mg-Zn-Al-Y base alloys. J.Mater.Research, (2004) 19(5),1531-1538.
23)Guangyin Yuan, Cunling Qin, Akihisa Inoue, Mg-Based Bulk Glassy Alloys with High Strength above 900MPa and Plastic StrainJ. Mater. Research, (2005) 20(2),394-400. times cited:16
24)Guangyin Yuan, Kenji Amiya, Akihisa Inoue, Structural-relaxation, glass-forming ability and mechanical properties of Mg-Cu-Ni-Gd alloys, J.Non-Crystalline Solids, 351(8-9)(2005)729-735. times cited:19
25)Guangyin Yuan, Akihisa Inoue, The effect of Ni substitution on the glass-forming ability and mechanical properties of Mg-Cu-Gd metallic glass alloys, J. Alloys and Compounds, (2005) 387(1-2),134-138. times cited:47
26)Guangyin Yuan, Tao Zhang, Akihisa Inoue,Structure and Mechanical Properties of Mg85Cu5Zn5Y5 Amorphous Alloys Containing Nanoscale particles, Materials Letters, (2004) 58(24),3012-3016.
27)Guangyin Yuan,Tao Zhang, Akihisa Inoue, Thermal Stability, Glass-Forming Ability and Mechanical Properties of Mg-Y-Zn-CuGlassy Alloys. Materials Transactions, (2003) 44(11),2271-2275. times cited:15
28)Yuan Guangyin, Liu Manping, Ding Wenjiang, Akihisa Inoue,Microstructure and mechanical properties of Mg-Zn-Si-based alloys, Mater. Sci.& Eng.(2003) A357(1-2),314-320. times cited:43
29)Yuan Guangyin, Liu Manping, Ding Wenjiang, Akihisa Inoue, Mechanical properties and microstructure of Mg-Al-Zn-Si-base alloy, Materials Transactions. (2003) 44(4),458-462. times cited:15
30)Guangyin Yuan, Zili Liu, Yisuan Wang and Wenjiang Ding, Microstructure refinement of Mg alloys containing Mg2Si , Materials Letters  (2002) 56,53-58. times cited:84
31)Manping Liu, Guangyin Yuan, Qudong Wang,etc.,Superplastic Behavior and Microstural Evolution of Commercial Mg-3Al-1Zn Magnesium Alloy, Materials Transactions,JIM, (2002) 43,2433-2436.
32)Yuan Guangyin, Wang Qudong, Ding Wenjiang, High temperature deformation behavior of permanent casting AZ91 alloy with and without Sb addition. Journal of Materials Science. (2002) 37,127-132. times cited:19
33)Yuan Guangyin, Sun Yangshan, Ding Wenjiang, Effects of bismuth and antimony additions on the microstructure and mechanical properties of AZ91 magnesium alloy, Mater. Sci. & Eng. (2001)A308(1-2), 38-44.  times cited:36
34)Yuan Guangyin, Sun Yangshan, Ding wenjiang, Effects of Sb addition on the microstructure and mechanical properties of AZ91 magnesium alloy, Scripta Mater. (2000) 43,1009-1013. times cited:64.
 
6. 代表性专利:
1) 袁广银,章晓波,丁文江,骨科用镁合金内植入材料及其制备方法,中国发明专利申请号:201010252357.0
2) 袁广银,章晓波,丁文江,生物体内可降解镁合金血管内支架的制备方法,中国发明专利申请号:201010204716.5
3) 袁广银,章晓波,丁文江,生物体内可降解高强韧耐蚀镁合金内植入材料,中国发明专利申请号:201010204719.9
4) 袁广银,尹健,丁文江,快速凝固超高强度镁合金及其制备方法,中国发明专利申请号:200910049871.1
5) 袁广银,丁文江,镁合金金属型铸造模具,实用新型专利,专利号:ZL 200720070727.2
6) 袁广银,刘勇,丁文江,自生准晶增强的高塑性变形镁合金,专利号:ZL 200610026842.X
7) 袁广银,丁文江,原位合成准晶及Laves相增强高性能耐热镁合金, 专利号:ZL 200510023281.3
8) 袁广银,丁文江,含Mg2Si强化相镁合金的组织细化熔铸工艺, 专利号:ZL01 1 26464.0
9) 袁广银,丁文江,汽车用多元耐热镁合金及其熔铸工艺, 专利号:ZL 01 1 26463.2
 
7. 获奖情况:
1)2007年上海市科技进步一等奖:高性能耐热镁合金及其在汽车中的应用,丁文江,卢晨,袁广银,曾小勤,王渠东,彭立明等;
22008上海市发明创造专利奖三等奖:汽车用多元耐热镁合金及其熔铸工艺, 袁广银,丁文江。
 
8. 实验设备:

高速冷冻离心机

 细胞培养箱

 酶标仪

 荧光倒置生物显微镜

 电泳仪

 百级净化台

 

超低温冰箱

生物材料医用净化室

高压蒸汽灭菌器

真空干燥箱

 

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